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- Title
Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning.
- Authors
Jun-Hyeok Choi; Pojeong Park; Gi-Chul Baek; Su-Eon Sim; SukJae Joshua Kang; Yeseul Lee; Seo-Hee Ahn; Chae-Seok Lim; Yong-Seok Lee; Collingridge, Graham L.; Bong-Kiun Kaang
- Abstract
Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the γ isoform of PI3K (PI3Kγ) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3Kγ in synaptic plasticity and hippocampus-dependent behavioral tasks we overexpressed p110γ, the catalytic subunit of PI3Kγ, in the hippocampal CA1 region. We found that the overexpression of p110γ impairs NMDA receptor-dependent long-term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-term potentiation (LTP) and contextual fear memory were not affected by p110γ overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3Kγ in the hippocampus is required for successful induction of LTD and normal learning.
- Subjects
NEUROPLASTICITY; HIPPOCAMPUS (Brain); PHYSIOLOGICAL adaptation; CEREBRAL cortex; LEARNING
- Publication
Molecular Brain, 2014, Vol 7, Issue 1, p1
- ISSN
1756-6606
- Publication type
Article
- DOI
10.1186/s13041-014-0078-6