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- Title
Does Spironolactone Have a Dose-Dependent Effect on Left Ventricular Remodeling in Patients with Preserved Left Ventricular Function After an Acute Myocardial Infarction?
- Authors
Vatankulu, Mehmet Akif; Bacaksiz, Ahmet; Sonmez, Osman; Alihanoglu, Yusuf; Koc, Fatih; Demir, Kenan; Gul, Enes Elvin; Turfan, Murat; Tasal, Abdurrahman; Kayrak, Mehmet; Yazici, Mehmet; Ozdemir, Kurtulus
- Abstract
Aims The aim of this study was to investigate the effects of spironolactone on left ventricular ( LV) remodeling in patients with preserved LV function following acute myocardial infarction ( AMI). Methods and Results Successfully revascularized patients (n = 186) with acute ST elevation MI ( STEMI) were included in the study. Patients were randomly divided into three groups, each of which was administered a different dose of spironolactone (12.5, 25 mg, or none). Echocardiography was performed within the first 3 days and at 6 months after MI. Echocardiography control was performed on 160 patients at a 6-month follow-up. The median left ventricular ejection fraction ( LVEF) increased significantly in all groups, but no significant difference was observed between groups ( P = 0.13). At the end of the sixth month, the myocardial performance index ( MPI) had improved in each of the three groups, but no significant difference was found between groups (F = 2.00, P = 0.15). The mean LV peak systolic velocities (Sm) increased only in the control group during the follow-up period, but there is no significant difference between groups (F = 1.79, P = 0.18). The left ventricular end-systolic volume index ( LVESVI) and the left ventricular end-diastolic volume index ( LVEDVI) did not change significantly compared with the basal values between groups (F = 0.05, P = 0.81 and F = 1.03, P = 0.31, respectively). Conclusion In conclusion, spironolactone dosages of up to 25 mg do not augment optimal medical treatment for LV remodeling in patients with preserved cardiac functions after AMI.
- Subjects
SPIRONOLACTONE; VENTRICULAR remodeling; MYOCARDIAL infarction treatment; MYOCARDIAL revascularization; ECHOCARDIOGRAPHY
- Publication
Cardiovascular Therapeutics, 2013, Vol 31, Issue 4, p224
- ISSN
1755-5914
- Publication type
Article
- DOI
10.1111/1755-5922.12006