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- Title
Strategies for using nanoprobes to perceive and treat cancer activity: a review.
- Authors
Byunghoon Kang; Kukreja, Aastha; Daesub Song; Yong-Min Huh; Seungjoo Haam
- Abstract
Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.
- Subjects
CANCER treatment; HEALTH planning; NANOMEDICINE; CANCER diagnosis; GENETIC regulation
- Publication
Journal of Biological Engineering, 2017, Vol 11, p1
- ISSN
1754-1611
- Publication type
Article
- DOI
10.1186/s13036-016-0044-1