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- Title
Clinicopathological Features of Non-Small Cell Lung Carcinoma with BRAF Mutation.
- Authors
Ambrosini-Spaltro, Andrea; Rengucci, Claudia; Capelli, Laura; Chiadini, Elisa; Calistri, Daniele; Bennati, Chiara; Cravero, Paola; Limarzi, Francesco; Nosseir, Sofia; Panzacchi, Riccardo; Valli, Mirca; Ulivi, Paola; Rossi, Giulio
- Abstract
(1) Background: BRAF mutations affect 4–5% of lung adenocarcinomas. This study aimed to analyze the clinicopathological features of lung carcinomas with BRAF mutations, focusing on V600E vs. non-V600E and the presence of co-mutations. (2) Methods: All BRAF-mutated lung carcinomas were retrieved from a molecular diagnostic unit (the reference unit for four different hospitals). The samples were analyzed using next-generation sequencing. Statistical analyses included log-rank tests for overall survival (OS) and progression-free survival (PFS). (3) Results: In total, 60 BRAF-mutated lung carcinomas were retrieved: 24 (40.0%) with V600E and 36 (60.0%) with non-V600E mutations, and 21 (35.0%) with other co-mutations and 39 (65.0%) with only BRAF mutations. Survival data were available for 54/60 (90.0%) cases. Targeted therapy was documented in 11 cases. Patients with V600E mutations exhibited a better prognosis than patients with non-V600E mutations (p = 0.008 for OS, p = 0.018 for PFS); this was confirmed in PFS (p = 0.036) when considering only patients who received no targeted therapy. Patients with co-mutations displayed no prognostic difference compared to patients carrying only BRAF mutations (p = 0.590 for OS, p = 0.938 for PFS). (4) Conclusions: BRAF-mutated lung carcinomas with V600E (40.0%) had a better prognosis than those without V600E. Concomitant co-mutations (35.0%) did not affect the prognosis.
- Subjects
BRAF genes; LUNGS; PROGRESSION-free survival; CLINICAL pathology; NUCLEOTIDE sequencing
- Publication
Current Oncology, 2023, Vol 30, Issue 11, p10019
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3390/curroncol30110728