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- Title
In vitro and in vivo evaluation of a new polysulfone membrane for hemodialysis. Reference methodology and clinical results. (Part. 2: in vivo study).
- Authors
Ronco, C; Brendolan, A; Cappelli, G; Ballestri, M; Inguaggiato, P; Fortunato, L; Milan, M; Pietribiasi, G; La Greca, G
- Abstract
Different high flux membranes have been recently developed. The present study is aimed at describing the technical features and the clinical performances of a new high flux polysulfone membrane (T-sulfone, Toray, Japan). The study has been carried out on two different dialyzers (surface area = 1.3 and 1.8 m2). The filters have been tested in vivo during hemodialysis and hemodiafiltration. The in vivo study was carried out on 12 ESRD patients on regular hemodialysis treatment. The protocol was reviewed and approved by the local ethical committee. The in vivo clearances (K) at 300 ml/min of blood flow are reported in the following Table: [Table in text]. Beta-2-m reduction ratio exceeded 50% in all sessions. Beta-2-m mass balance executed by collection of spent dialysate and elution from the used filters evidenced that removal is obtained mostly by filtration while absorption is negligible. Excellent tolerance and hemocompatibility was observed in all the studied sessions.
- Subjects
TREATMENT of chronic kidney failure; ADSORPTION (Chemistry); BIOMEDICAL materials; BLOOD proteins; COMPARATIVE studies; GLOBULINS; HEMODIALYSIS; RESEARCH methodology; MEDICAL cooperation; ARTIFICIAL membranes; POLYMERS; RESEARCH; SULFONES; EVALUATION research; HEMODIAFILTRATION; EQUIPMENT &; supplies
- Publication
International Journal of Artificial Organs, 1999, Vol 22, Issue 9, p616
- ISSN
0391-3988
- Publication type
journal article
- DOI
10.1177/039139889902200905