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- Title
Human T Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis in São Paulo, Brazil.
- Authors
Domingues, R. B.; Muniz, M. R.; Pinho, J. R. R.; Bassit, L.; Jorge, M. L. C.; Saez Alquezar, A.; Marchiori, P. E.; Chamone, D. F.; Scaff, M.
- Abstract
We conducted a prospective clinical and epidemiologic evaluation of 45 cases of human T lymphotropic virus type I (HTLV-1)—associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Sao Paulo, Brazil. All enrolled patients had progressive chronic myelopathy and high titers of HTLV-I and HTLV-II antibodies, as determined by enzyme immunoassay and western blot. In 24 cases, the polymerase chain reaction (PCR) was performed so that HTLV-I could be distinguished from HTLV-II. The clinical and epidemiologic features of the patients from our study were similar to those of patients with HAM/TSP from other areas of endemicity for HTLV-I except that more patients in our study had received a blood transfusion prior to their illness. Despite the presence of HTLV-II virus in Brazil, all patients whose serum was tested by PCR were found to be infected with the HTLV-I virus.
- Publication
Clinical Infectious Diseases, 1995, Vol 20, Issue 6, p1540
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/clinids/20.6.1540