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- Title
Highly Site Selective Formal [5+2] and [4+2] Annulations of Isoxazoles with Heterosubstituted Alkynes by Platinum Catalysis: Rapid Access to Functionalized 1,3-Oxazepines and 2,5-Dihydropyridines.
- Authors
Shen, Wen-Bo; Xiao, Xin-Yu; Sun, Qing; Zhou, Bo; Zhu, Xin-Qi; Yan, Juan-Zhu; Lu, Xin; Ye, Long-Wu
- Abstract
Platinum-catalyzed formal [5+2] and [4+2] annulations of isoxazoles with heterosubstituted alkynes enabled the atom-economical synthesis of valuable 1,3-oxazepines and 2,5-dihydropyridines, respectively. Importantly, this Pt catalysis not only led to unique reactivity dramatically divergent from that observed under Au catalysis, but also proceeded via unprecedented α-imino platinum carbene intermediates.
- Subjects
ISOXAZOLES; ALKYNES; PLATINUM catalysts; DIHYDROPYRIDINE; METAL carbenes; YNAMIDES
- Publication
Angewandte Chemie International Edition, 2017, Vol 56, Issue 2, p605
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201610042