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- Title
Selective Oxytrifluoromethylation of Allylamines with CO<sub>2</sub>.
- Authors
Ye, Jian-Heng; Song, Lei; Zhou, Wen-Jun; Ju, Tao; Yin, Zhu-Bao; Yan, Si-Shun; Zhang, Zhen; Li, Jing; Yu, Da-Gang
- Abstract
Reported is the first oxy-trifluoromethylation of allylamines with carbon dioxide (CO2) using copper catalysis, thus leading to important CF3-containing 2-oxazolidones. It is also the first time CO2, a nontoxic and easily available greenhouse gas, has been used to tune the difunctionalization of alkenes from amino- to oxy-trifluoromethylation. Of particular note, this multicomponent reaction is highly chemo-, regio-, and diastereoselective under redox-neutral and mild reaction conditions. Moreover, these reactions feature good functional-group tolerance, broad substrate scope, easy scalability and facile product diversification. The important products could also be formed with either spirocycles or two adjacent tetrasubstituted carbon centers.
- Subjects
METHYLATION; ALLYLAMINES; CARBON dioxide; COPPER catalysts; ALKENES
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 34, p10022
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201603352