We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mixing Biomimetic Heterodimers of Nucleopeptides to Generate Biocompatible and Biostable Supramolecular Hydrogels.
- Authors
Dan Yuan; Xuewen Du; Junfeng Shi; Ning Zhou; Jie Zhou; Bing Xu
- Abstract
As a new class of biomaterials, most supramolecular hydrogels formed by small peptides require the attachment of long alkyl chains, multiple aromatic groups, or strong electrostatic interactions. Based on the fact that the most abundant protein assemblies in nature are dimeric, we select short peptide sequences from the interface of a heterodimer of proteins with known crystal structure to conjugate with nucleobases to form nucleopeptides. Being driven mainly by hydrogen bonds, the nucleopeptides self-assemble to form nanofibers, which results in supramolecular hydrogels upon simple mixing of two distinct nucleopeptides in water. Moreover, besides being biocompatible to mammalian cells, the heterodimer of the nucleopeptides exhibit excellent proteolytic resistance against proteinase K. This work illustrates a new and rational approach to create soft biomaterials by a supramolecular hydrogelation triggered by mixing heterodimeric nucleopeptides.
- Subjects
BIOMIMETIC chemicals; CHEMICALS; HETERODIMERS; SUPRAMOLECULES; NANOFIBERS; CRYSTAL structure
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 19, p5705
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201412448