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- Title
PET Imaging of Bacterial Infections with Fluorine-18-Labeled Maltohexaose.
- Authors
Ning, Xinghai; Seo, Wonewoo; Lee, Seungjun; Takemiya, Kiyoko; Rafi, Mohammad; Feng, Xuli; Weiss, Daiana; Wang, Xiaojian; Williams, Larry; Camp, Vernon M.; Eugene, Malveaux; Taylor, W. Robert; Goodman, Mark; Murthy, Niren
- Abstract
A positron emission tomography (PET) tracer composed of 18F-labeled maltohexaose (MH18F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose (18FDG). MH18F can detect early-stage infections composed of as few as 105 E. coli colony-forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH18F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.
- Subjects
BACTERIAL diseases; FLUORODEOXYGLUCOSE F18; POSITRON emission tomography; ESCHERICHIA coli; BACTERIAL colonies
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 51, p14096
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201408533