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- Title
A General Palladium-Catalyzed Method for Alkylation of Heteroarenes Using Secondary and Tertiary Alkyl Halides.
- Authors
Wu, Xiaojin; See, Jessica Wei Ting; Xu, Kai; Hirao, Hajime; Roger, Julien; Hierso, Jean‐Cyrille; Zhou, Jianrong (Steve)
- Abstract
A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.
- Subjects
PALLADIUM catalysts; HETEROARENES; ALKYLATION; HALOALKANES; INDOLE compounds; PYRIDINE
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 49, p13573
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201408355