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- Title
Inside Back Cover: Direct Asymmetric Vinylogous Aldol Reaction of Allyl Ketones with Isatins: Divergent Synthesis of 3-Hydroxy-2-Oxindole Derivatives (Angew. Chem. Int. Ed. 26/2013).
- Authors
Zhu, Bo; Zhang, Wen; Lee, Richmond; Han, Zhiqiang; Yang, Wenguo; Tan, Davin; Huang, Kuo‐Wei; Jiang, Zhiyong
- Abstract
Acyclic allyl ketones are rarely employed as nucleophiles in vinylogous reactions owing to the low electron density at the γ position of the dienolates. In their Communication on page 6666 ff., K.‐W. Huang, Z. Jiang, and co‐workers demonstrate that with a proper catalyst design, a direct enantioselective vinylogous aldol reaction of allyl ketones to isatins can be achieved with a broad scope for the collective synthesis of 3‐hydroxy‐2‐oxindoles which have important biological activities.
- Subjects
ANGEWANDTE Chemie (Periodical); KETONES
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 26, p6785
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201304259