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- Title
Construction of Enantiomerically Enriched Diazo Compounds Using Diazo Esters as Nucleophiles: Chiral Lewis Base Catalysis.
- Authors
Mao, Haibin; Lin, Aijun; Shi, Yan; Mao, Zhijie; Zhu, Xuebin; Li, Weipeng; Hu, Hongwen; Cheng, Yixiang; Zhu, Chengjian
- Abstract
Amazing diazo: The title reaction leads to highly functionalized diazo compounds in good yields with excellent enantioselectivities (see scheme; Boc=tert‐butoxycarbonyl). The utility of the products was demonstrated by the rapid synthesis of a number of optically pure nitrogen heterocycles. The key to this process was the use of 2,2,2‐trifluoroethyl diazoacetate as a superior nucleophilic reagent.
- Subjects
DIAZO compounds; NUCLEOPHILIC reactions; CHIRALITY; CATALYSIS; ALKYLATION; CARBONATES; HETEROCYCLIC compounds
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 24, p6288
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201301509