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- Title
Inside Cover: Rational Design of an Apoptosis-Inducing Photoreactive DNA Intercalator (Angew. Chem. Int. Ed. 24/2013).
- Authors
Ueberschaar, Nico; Dahse, Hans‐Martin; Bretschneider, Tom; Hertweck, Christian
- Abstract
Vinylchartreusin , a chartreusin analogue that intercalates in double‐stranded DNA, was prepared by mutasynthesis to design a photoactivatable antitumoral agent that is able to form [2+2] photoadducts. In their Communication on page 6185 ff., C. Hertweck and co‐workers report substantially higher antiproliferative activities of this compound compared with the natural product upon irradiation with visible light. Colorectal cancer cells (see background) show signs of apoptosis after treatment with vinylchartreusin and blue light.
- Subjects
COLON cancer treatment; CANCER cells; APOPTOSIS
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 24, p6114
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201303645