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- Title
Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn<sup>2+</sup> in cognitively intact aged individuals with Alzheimer's disease neuropathology.
- Abstract
The article presents a study which shows the putative resistance mechanism in non-demented with Alzheimer's disease neuropathology (NDAN) cases, which may indicate potential AD treatment. The study performed various procedures including immunohistochemistry, enzyme-linked immunosrbent assay (ELISA) and western immunoblotting. Results show that amyloid (Aβ) oligomers do not exist in hippocampal postsynapses in NDAN cases, despite its presence in soluble fractions.
- Subjects
AMYLOID beta-protein; ALZHEIMER'S disease treatment; HIPPOCAMPUS physiology; IMMUNOHISTOCHEMISTRY; ENZYME-linked immunosorbent assay; WESTERN immunoblotting; SYNAPSES; OLIGOMERS; PHYSIOLOGY
- Publication
Molecular Neurodegeneration, 2012, Vol 7, Issue 1, p23
- ISSN
1750-1326
- Publication type
Article
- DOI
10.1186/1750-1326-7-23