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- Title
Fusarium proliferatum as a dominant Fusarium species isolated from patients with onychomycosis in the North of Iran.
- Authors
Haghani, Iman; Shams-Ghahfarokhi, Masoomeh; Asl, Abdolhossein Dalimi; Shokohi, Tahereh; Hedayati, Mohammad Taghi; Fathi, Maryam
- Abstract
Introduction: Onychomycosis refers to any fungal infection of the nail and is usually caused by dermatophytes; however, non-dermatophyte molds (NDMs) and yeasts are increasingly recognized as the pathogens accounting for nail disease. Several studies have shown that Fusarium is the most common NDMs causing onychomycosis and its spread has increased in the past years. Materials and Methods: The present study was conducted to describe the molecular epidemiology of Fusarium onychomycosis in the north of Iran. 257 nail samples collected from the Iranian patients clinically suspected of onychomycosis were subjected to direct microscopy, calcofluor white staining, and fungal culture. The characteristics of Fusarium isolates were further identified at a species level by determining multi-locus sequences for internal transcribed spacer and translation elongation factor 1 alpha. Result: According to the results, Fusarium species were isolated from 27 patients with onychomycosis. Based on previous partial genes analysis, the recognized species in our study were among the members of F. fujikuroi species complex (n=14), F. solani species complex (n=12), and Fusarium incarnatum-equiseti species complex (n=1). In the present study, F. proliferatum was the dominant Fusarium species isolated from the samples. Conclusion: With regard to the increased prevalence of Fusarium onychomycosis and the intrinsic resistance of Fusarium species to a broad range of antifungals, it is necessary to correctly identify them to the species level.
- Subjects
IRAN; ONYCHOMYCOSIS; CONFERENCES &; conventions; DIAGNOSIS
- Publication
Current Medical Mycology, 2018, Vol 4, p64
- ISSN
2423-3439
- Publication type
Article
- DOI
10.18502/cmm.4.S1.2018.180