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- Title
Acquisition of a Philadelphia chromosome concomitant with transformation of a refractory anemia into an acute leukemia.
- Authors
Smadja, N.; Krulik, M.; De Gramont, A.; Brissaud, P.; Debray, J.
- Abstract
The authors present a case of Philadelphia (Ph1) positive acute myeloblastic leukemia (AML) following a refractory anemia with excess of blasts (RAEB) that had been Ph1-negative for 17 months. During the transformation of RAEB into AML, the Ph1 was discovered in 100% of the examined cells. With therapy a partial remission was obtained, during which some 46,XY cells reappeared mixed with Ph1 cells along with a new clone: 47,XY,+11 originating from a Ph1-negative cell. During the terminal blast crisis, the karyotype returned to 46,XY,Ph1. The AML lasted 21 months. The authors discuss: (1) the significance of Ph1-positive AML with a review of the literature; (2) the de novo acquisition of a Ph1 during the course of a blood disorder; and (3) the meaning of a second abnormal clone originating from 46,XY cells.
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 7, p1477
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850401)55:7<1477::AID-CNCR2820550710>3.0.CO;2-A