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- Title
Leukocyte migration inhibition of leukemia-associated antigen in children with acute leukemia and their family members.
- Authors
Hann, Hie-Won L.; London, W. Thomas; Evans, Audrey E.; Hann, R. Suhung; Hann, H W; London, W T; Evans, A E; Hann, R S
- Abstract
The leukocyte migration inhibition assay has been widely used as an in vitro test cell mediated immunity to various substances. Using a leukemic cell line (RPMI 8402) as the source of antigen, we assayed leukocyte migration inhibition in seven children with acute lymphocytic leukemic (ALL), their family members (14 patients and 13 siblings), and 17 healthy adult controls. In six families, the patients showed stronger inhibition than their family members or controls. The patients differed significantly from their family members (P = 0.003) and all other persons without leukemia (P = 0.02). These results suggest that patients with ALL have developed a specific cellular immune reactivity to an antigen or antigens on leukemic cells, while their family members have not.
- Publication
Cancer (0008543X), 1980, Vol 46, Issue 2, p293
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19800715)46:2<293::AID-CNCR2820460213>3.0.CO;2-2