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- Title
Relationship of a T-lymphocyte marker to phase of cell cycle and morphology of leukemic cells.
- Authors
Arlin, Zalmen A.; Chiao, Jen Wei; Fried, Jerrold; Dowling, Monroe D.; Clarkson, Bayard D.; Good, Robert A.; Arlin, Z A; Chiao, J W; Fried, J; Dowling, M D Jr; Clarkson, B D; Good, R A
- Abstract
Spontaneous rosette formation with sheep erythrocytes (SRBC) was studied in the peripheral blood and bone marrow lymphoid cells from a patient whose leukemic cells appeared to be T-lymphocytes. Simultaneous morphological examination of the peripheral blood white cells indicated that they consisted of 21% lymphoblast; 26% prolymphocytes and 48% mature lymphocytes. The distribution of bone marrow cells within the cell cycle was determined by flow microfluorometry and 7 hours after treatment with vincristine consisted of 69% in G1, 21% in S, and 9% in mitosis. Since virtually all the cells both in marrow and blood formed rosettes with SRBC this implies that the expression of this T cell marker is independent both of the morphological appearance of these cells and their position within the cell cycle.
- Publication
Cancer (0008543X), 1977, Vol 39, Issue 3, p1101
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197703)39:3<1101::AID-CNCR2820390314>3.0.CO;2-4