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- Title
In vitro quality parameters of whole blood‐derived platelets pooled using two different platelet pooling sets and stored up to 7 days are similar.
- Authors
Vandenbroeke, Tania; Gloor, Christina; Wingfield, Tyler; Leite, Caroline; Carr, Kathlynn; Turner, Chris; Ngamsuntikul, Samantha; Sutor, Laurie; Compton, Frances; Nestheide, Shawnagay; Rugg, Neeta; Cancelas, Jose A.; Dumont, Larry J.
- Abstract
Background: Increasing the number of collections of whole blood‐derived platelets (WBDP) and lengthening the allowable storage time may alleviate platelet (PLT) shortages. There is a need for new PLT pooling sets that can provide acceptable quality on Day 7 of storage. Study Design and Methods: This pool‐and‐split study compared WBDP prepared using the platelet‐rich plasma method with the novel IMUGARD WB PLT pooling set and a control pooling set. After pooling and filtration, PLT products were tested on Days 1, 5, and 7. Large volume delayed sampling (LVDS) cultures were taken on Day 2. Results: The median postfiltration residual white blood cell (rWBC) content was 0.18 million per product (maximum 1.26 million; n = 69) with mean PLT recovery of 88.5 ± 2.8% for the new set and median 0.23 million (maximum 1.83 million) rWBC with 87.5 ± 2.5% recovery for the control. Day 5 mean pH22°C were 7.18 ± 0.12 and 7.13 ± 0.10 for the new and control set, respectively. Day 5 in vitro quality parameters were within 20% between the two pooling sets. The new set Day 7 pH22°C was acceptable (7.07 ± 0.17, 100% ≥ 6.3), and most parameters were within 20% of Day 5 values. Conclusion: WBDP quality for the new pooling set is acceptable across a battery of in vitro tests when stored up to 7 days and meets FDA regulatory criteria. The quality parameters were similar between the new pooling set and the control set on Day 5. This new set is compatible with LVDS.
- Subjects
UNITED States. Food &; Drug Administration; BLOOD platelets; LEUCOCYTES; PLATELET-rich plasma; INTEGERS
- Publication
Transfusion, 2024, Vol 64, Issue 1, p132
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.17591