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- Title
Seasonal variability is not observed in the rates of high anti-A and anti-B titers in plasma, apheresis platelet, and whole blood units tested by different methods.
- Authors
Harm, Sarah K.; Yazer, Mark H.; Bub, Carolina B.; Cohn, Claudia S.; Jacob, Eapen K.; Kutner, Jose M.; Mair, David C.; Raval, Jay S.; Shaz, Beth H.; Ziman, Alyssa; Dunbar, Nancy M.; Biomedical Excellence for Safer Transfusion (BEST) Collaborative
- Abstract
<bold>Background: </bold>ABO-incompatible platelet transfusions are common, and transfusions with ABO-incompatible plasma are increasing with the use of group A plasma and group O whole blood (WB) in emergencies. Many centers screen blood products for anti-A and/or anti-B titers to help prevent hemolysis from ABO-incompatible transfusions, yet titer methods and definition of high titers are not standardized.<bold>Study Design and Methods: </bold>This international multicenter study collected data on anti-A and anti-B titer practices for plasma, apheresis platelet (AP), and WB units from January 2015 through December 2017 to determine the prevalence of high-titer units using local definitions.<bold>Results: </bold>A total of 87,701 plasma, AP and WB units were screened for high-titer anti-A and/or anti-B. High-titer detection rates for group A plasma ranged 0%-13.6%; group A AP 2.7%-9.3%; group O AP 2.3%-65.7%; and group O WB 6.4%-20.7%. At the one center that collected group B AP, the high-titer rate was 10.9%. High-titer rates varied from month to month, as well as between years for a given month. There was no clear pattern of when high-titer units were donated.<bold>Conclusion: </bold>The prevalence of high-titer plasma, AP, and WB units varies by titer method and local definition of high titer. Even at the lowest titer threshold of 50, a significant proportion of units had a high-titer antibody, although the clinical relevance of this finding needs further investigation.
- Subjects
ABO blood group system; TITERS; BLOOD group incompatibility; BLOOD testing; PLASMA gases; BLOOD products; BLOOD platelet transfusion
- Publication
Transfusion, 2019, Vol 59, Issue 2, p762
- ISSN
0041-1132
- Publication type
journal article
- DOI
10.1111/trf.15083