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- Title
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
- Authors
Cerhan, James R; Slager, Susan L; Nieters, Alexandra; Cox, David; Veron, Amelie S; Monnereau, Alain; Flowers, Christopher R; De Roos, Anneclaire J; Brooks-Wilson, Angela R; Severi, Gianluca; Melbye, Mads; Gu, Jian; Ye, Yuanqing; Wu, Xifeng; Jackson, Rebecca D; Berndt, Sonja I; Lan, Qing; Purdue, Mark P; Albanes, Demetrius; Hartge, Patricia
- Abstract
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10−21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10−10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10−8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10−13 and 3.63 × 10−11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
- Subjects
LYMPHOMAS; GENOMICS; GENOTYPES; DISEASE susceptibility; SINGLE nucleotide polymorphisms; GENETICS
- Publication
Nature Genetics, 2014, Vol 46, Issue 11, p1233
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.3105