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- Title
Syntheses of (+)-costic acid and structurally related eudesmane sesquiterpenoids and their biological evaluations as acaricidal agents against Varroa destructor.
- Authors
Kenji Nemoto; Hirosato Takikawa; Yusuke Ogura
- Abstract
Synthesis of (+)-costic acid, isolated from Dittrichia viscosa (L.) W. Greuter as a natural acaricidal sesquiterpenoid, was achieved in 16 steps from (R)-carvone with an overall yield of 4.8%, involving the radical cyclization of selenoester to construct a decalone framework as the key step. Other structurally related natural products, (+)-costal, (+)-costol, and (+)-β-selinene, were also synthesized. The acaricidal activities of these four natural products and some synthetic intermediates were also evaluated against Varroa destructor. Among them, (+)-costal especially exhibited potent acaricidal activity.
- Subjects
VARROA destructor; SESQUITERPENES; SYNTHETIC products; NATURAL products; RADICALS (Chemistry); SELENOPROTEINS
- Publication
Journal of Pesticide Science, 2023, Vol 48, Issue 3, p111
- ISSN
1348-589X
- Publication type
Article
- DOI
10.1584/jpestics.D23-029