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- Title
Liquid biopsy identifies actionable dynamic predictors of resistance to Trastuzumab Emtansine (T-DM1) in advanced HER2-positive breast cancer.
- Authors
Allegretti, Matteo; Fabi, Alessandra; Giordani, Elena; Ercolani, Cristiana; Romania, Paolo; Nisticò, Cecilia; Gasparro, Simona; Barberi, Vittoria; Ciolina, Maria; Pescarmona, Edoardo; Giannarelli, Diana; Ciliberto, Gennaro; Cognetti, Francesco; Giacomini, Patrizio
- Abstract
HER2 amplification was assessed in the last tumor tissue available before T-DM1 administration vs a tumor re-biopsy collected at disease progression from the same patients (n = 4). HER2 counterselection in blood was confirmed in 3/4 matched (from the same patient) tumor re-biopsies at progression, the only exception being a HER2-positive brain metastasis developing against a HER2-neutral blood background (pt#5; Fig. Keywords: HER2+ breast cancer; T-DM1; Liquid biopsy; Circulating tumor DNA; Pharmacological resistance EN HER2+ breast cancer T-DM1 Liquid biopsy Circulating tumor DNA Pharmacological resistance 1 6 6 11/30/21 20211129 NES 211129 Matteo Allegretti and Alessandra Fabi contributed equally to this work.
- Subjects
HER2 positive breast cancer; METASTATIC breast cancer; TRASTUZUMAB; MONONUCLEAR leukocytes; CELL-free DNA
- Publication
Molecular Cancer, 2021, Vol 20, Issue 1, p1
- ISSN
1476-4598
- Publication type
Article
- DOI
10.1186/s12943-021-01438-z