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- Title
The usefulness of cytogenetic analysis in fine needle aspirates for the histologic subtyping of sarcomas.
- Authors
Kilpatrick, Scott E.; Bergman, Simon; Pettenati, Mark J.; Gulley, Margaret L.
- Abstract
Conventional cytogenetic analysis performed from open biopsy tissue samples may be a useful adjunct for the histologic subtyping of bone and soft tissue sarcomas. However, its diagnostic utility in fine needle aspiration biopsy (FNAB) specimens is unclear. We retrospectively reviewed 24 consecutive FNAB bone and soft tissue sarcoma specimens, procured from 1995 to 2003, in which aspirated material was obtained for cytogenetic analysis. The study sample included eight Ewing sarcomas, six synovial sarcomas, five rhabdomyosarcomas, two myxoid liposarcomas, and one each of myxoid chondrosarcoma, osteosarcoma, and atypical lipoma. Cytogenetic analysis confirmed the t(X;18) in all six synovial sarcomas and the t(11;22) in three Ewing sarcomas. The t(2;13) was strongly suggested in one alveolar rhabdomyosarcoma. For two of these cases (both of which were synovial sarcomas), cytogenetic analysis was necessary for definitive diagnosis. While the positive cytogenetic results were supportive in the remainder, all were initially and accurately subtyped based on cytomorphology and/or immunohistochemistry. Cytogenetic analysis was noncontributory (eg no growth) in 14 sarcoma cases, but excluding the case of atypical lipoma, this did not preclude the rendering of an accurate diagnosis. Cytogenetic analysis can be performed on FNAB specimens from bone and soft tissue sarcomas and may be a useful diagnostic aid in difficult cases. However, when cell block material is available for immunohistochemistry, the majority of such cases are successfully subtyped.Modern Pathology (2006) 19, 815–819. doi:10.1038/modpathol.3800598; published online 24 March 2006
- Subjects
SARCOMA; CANCER; CYTOGENETICS; CYTOLOGY; TUMORS
- Publication
Modern Pathology, 2006, Vol 19, Issue 6, p815
- ISSN
0893-3952
- Publication type
Article
- DOI
10.1038/modpathol.3800598