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- Title
Mature B-cell acute lymphoblastic leukemia with t(9;11) translocation: a distinct subset of B-cell acute lymphoblastic leukemia.
- Authors
Tsao, Lawrence; Draoua, Hediya Y.; Osunkwo, Ifeyinwa; Nandula, Subhadra V.; Murty, Vundavalli V.S.; Mansukhani, Mahesh; Bhagat, Govind; Alobeid, Bachir
- Abstract
Mature B-cell acute lymphoblastic leukemia (ALL) is typically associated with the FAB-L3 morphology and rearrangement of the MYC gene, features characteristic of the leukemic phase of Burkitt's lymphoma. However, the term ‘mature’ has also been used to describe other rare cases of B-ALL with light-chain surface immunoglobulin expression. In contrast, infantile B-cell ALL is generally characterized by rearrangement of the MLL gene, an immature pro-B-cell phenotype, and CD10 negativity. We describe two unusual cases of infantile B-ALL with non-L3 morphology, expressing a mature B-cell phenotype (? sIg+, CD19+, CD10-, TdT-, and CD34-), and showing MLL rearrangement without MYC rearrangement at presentation. Both infants relapsed after months of morphologic and genetic remission. At relapse, the t(9;11) translocation was detected in both cases by spectral karyotyping. After the initial relapse, both cases followed a rapid and aggressive course. Literature search identified few similar cases, all expressed ? surface immunoglobulin and showed MLL rearrangement (majority with the t(9;11) translocation). These cases show that B-ALL with MLL rearrangement, especially the t(9;11) translocation, can express a ‘mature’ B-cell phenotype and may represent a distinct subset. Identification of additional cases will further clarify the significance of MLL rearrangements in mature B-ALL.Modern Pathology (2004) 17, 832-839, advance online publication, 16 April 2004; doi:10.1038/modpathol.3800128
- Subjects
LYMPHOBLASTIC leukemia; B cell lymphoma; CHROMOSOMAL translocation; LEUKEMIA; TUMORS in children; CARCINOGENESIS
- Publication
Modern Pathology, 2004, Vol 17, Issue 7, p832
- ISSN
0893-3952
- Publication type
Article
- DOI
10.1038/modpathol.3800128