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- Title
Selection of human blastocysts with a high implantation potential based on timely compaction.
- Authors
Mizobe, Yamato; Ezono, Yuji; Tokunaga, Makoto; Oya, Naoto; Iwakiri, Reiko; Yoshida, Naomi; Sato, Yumi; Onoue, Nanase; Miyoshi, Kazuchika
- Abstract
Purpose: Recently, we established a noninvasive system for selecting human blastocysts with a high pre-transfer implantation potential based on first and second division patterns. The present study was carried out to improve the selection system. Methods: Embryos that completed first and second divisions within 25.90 and 37.88 h after culture, respectively, were selected using a time-lapse incubator. We examined the effects of compaction and blastocyst formation times on pregnancy rates after transferring these embryos at the blastocyst stage. Results: The completion of compaction and blastocyst formation times (79.93 and 97.47 h after culture, respectively) of embryos resulting in pregnancies after transfer were significantly ( P < 0.01) shorter than those (86.46 and 100.34 h after culture, respectively) of embryos that failed to induce pregnancies. Embryo selection based on completion of compaction time improved pregnancy rates (40.9 vs. 74.6%, P < 0.01). Conclusions: Of the embryos that formed two cells during the first division within 25.90 h after culture and four cells during the second division within 37.88 h after culture, those that completed compaction within 79.93 h after culture before reaching the blastocyst stage had a high implantation potential.
- Subjects
BLASTOCYST; HUMAN embryos; PREGNANCY; INFANT incubators; HUMAN reproductive technology
- Publication
Journal of Assisted Reproduction & Genetics, 2017, Vol 34, Issue 8, p991
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-017-0962-y