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- Title
Identification and Biological Activities of Bryostatins from Japanese Bryozoan.
- Authors
Ueno, Sayo; Yanagita, Ryo C.; Murakami, Kazuma; Murakami, Akira; Tokuda, Harukuni; Suzuki, Nobutaka; Fujiwara, Takeshi; Irie, Kazuhiro
- Abstract
The article discusses identification and determination of biological activities of macrolide lactones bryostatins that was isolated from bryozoan moss animals species. The structural analysis of bryostatins reveals that ester group at 20th position of carbon is not necessary for binding and activation of Protein Kinase C. The anti tumor properties of bryostatins in induction tests with the epstein barr virus early antigen is also included.
- Subjects
BRYOZOA; EPSTEIN-Barr virus; ANTIGENS; PROTEIN kinase C; ESTERS; ANTINEOPLASTIC agents; LACTONES
- Publication
Bioscience, Biotechnology & Biochemistry, 2012, Vol 76, Issue 5, p1041
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.120026