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- Title
HSP40 Ameliorates Impairment of Insulin Secretion by Inhibiting Huntingtin Aggregation in a HD Pancreatic β Cell Model.
- Authors
Cui-Fang Ye; He Li
- Abstract
The article presents a study on the effects of transiently transfected mutant huntingtin on the insulin content and Akt activities. It notes that Huntington's disease (HD) is a neurological disorder wherein the protein huntingtin contains glutamine which repeats to expand about 37 more glutamines. With this, various methods are used including cell culture and transfection, fluorescent microscopy, and statistical analysis. The result shows link of insulin to the aggregate formation of huntingtin.
- Subjects
HUNTINGTON disease; INSULIN synthesis inhibitors; NEUROLOGICAL disorders; GLUTAMINE; CELL aggregation; HEAT shock proteins
- Publication
Bioscience, Biotechnology & Biochemistry, 2009, Vol 73, Issue 8, p1787
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.90147