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- Title
RAFT Polymerization of 4-Vinylphenylboronic Acid as the Basis for Micellar Sugar Sensors.
- Authors
Maji, Samarendra; Vancoillie, Gertjan; Voorhaar, Lenny; Zhang, Qilu; Hoogenboom, Richard
- Abstract
Well-defined homo and mPEGylated block (co)polymers of the commercially available unprotected 4-vinylphenylboronic acid (4-VBA) monomer are reported based on reversible addition-fragmentation chain transfer (RAFT) polymerization. The polymerization kinetics are studied in detail for homo and block (co)polymerizations with different chain transfer agents (CTAs) to optimize the preparation of well-defined polymer structures, eventually leading to comparatively low dispersities ( Đ ≤ 1.25). Subsequently, block (co)polymers with methoxy poly(ethylene glycol) mPEG- b-P(4-VBA) are prepared using a mPEG-functionalized CTA. The formed block copolymer mPEG114- b-P(4-VBA)30 is demonstrated to be pH and glucose responsive as its micellization behavior is dictated by pH as well as the presence of glucose. The glucose-responsive pH window of mPEG114- b-P(4-VBA)30 is found to be pH 9-10 based on the DLS and TEM measurement.
- Subjects
POLYMERIZATION; BORONIC acids; MICELLAR solutions; CHEMICAL detectors; TRANSMISSION electron microscopy; COMPARATIVE studies
- Publication
Macromolecular Rapid Communications, 2014, Vol 35, Issue 2, p214
- ISSN
1022-1336
- Publication type
Article
- DOI
10.1002/marc.201300540