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- Title
Coupled expression of dipeptidyl peptidase-IV and fibroblast activation protein-α in transformed astrocytic cells.
- Authors
Balaziova, Eva; Busek, Petr; Stremenova, Jarmila; Sromova, Lucie; Krepela, Evzen; Lizcova, Libuse; Sedo, Aleksi
- Abstract
Dipeptidyl peptidase-IV (DPP-IV) and fibroblast activation protein-α (FAP) are speculated to participate in the regulation of multiple biological processes, because of their unique enzymatic activity, as well as by non-hydrolytic molecular interactions. At present, the role of DPP-IV and FAP in the development and progression of various types of tumors, including glioblastoma, is intensively studied, and their functional crosstalk is hypothesized. In this article, we describe the correlative expression of DPP-IV and FAP mRNA in primary cell cultures derived from human glioblastoma and associated expression dynamics of both molecules in astrocytoma cell lines depending on culture conditions. Although the molecular mechanisms of DPP-IV and FAP co-regulations remain unclear, uncoupled expression of transgenic DPP-IV and the endogenous FAP suggests that it occurs rather at the transcriptional than at the posttranscriptional level. Understanding of the expressional and functional coordinations of DPP-IV and FAP may help clarify the mechanisms of biological roles of both molecules in transformed astrocytic cells.
- Subjects
PEPTIDASE; FIBROBLASTS; ASTROCYTES; PROTEIN research; GLIOBLASTOMA multiforme
- Publication
Molecular & Cellular Biochemistry, 2011, Vol 354, Issue 1/2, p283
- ISSN
0300-8177
- Publication type
Article
- DOI
10.1007/s11010-011-0828-z