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- Title
Development of a novel ablation hood to prevent systemic embolization of microbubbles and particulate emboli.
- Authors
Sugrue, Alan; Vaidya, Vaibhav; Yasin, Omar; Isath, Ameesh; Abudan, Anas; Padmanabhan, Deepak; Kapa, Suraj; Asirvatham, Samuel J.
- Abstract
<bold>Background: </bold>Atrial fibrillation ablation results in microbubbles and particulate emboli formation. We aimed to develop and test the early feasibility of a novel ablation hood to contain microbubbles and particulate emboli with the ultimate goal of preventing systemic embolization.<bold>Methods: </bold>In seven canines, we developed, iterated, and tested a novel retractable hood that can cover the catheter-tissue ablation site. The number and volume (nL) of microbubbles formed during ablation with and without the hood was measured using an extracorporeal circulation loop. Wilcoxon's signed-rank test was used to compare the number of bubbles detected with and without the hood.<bold>Results: </bold>The hood reduced systemic embolization of microbubbles in 21/28 (75%) of ablations. Both atrial and ventricular ablations showed a statistically significant reduction in bubble number (476 ± 811 without hood vs 173 ± 226 with hood, p = 0.02; 2669 ± 1623 without hood vs 1417 ± 970 with hood, p = 0.04, respectively) and bubble volume (3.3 ± 7.6 nL without hood vs 0.2 ± 0.56 nL with hood, p = 0.006; 6.1 ± 5.2 nL without hood vs 1.9 ± 1.4 nL with hood, p = 0.05, respectively).<bold>Conclusions: </bold>Use of a novel hood to cover the ablation catheter at the site of catheter-tissue contact has the potential to provide a means to reduce systematic embolization of microbubbles. Further work is required to examine particulate emboli, but these data show the early feasibility of this design concept.
- Subjects
MICROBUBBLE diagnosis; MICROBUBBLES; WILCOXON signed-rank test; CATHETER ablation; ARTIFICIAL blood circulation; ATRIAL fibrillation; EMBOLISMS; EQUIPMENT &; supplies; HEART atrium; DOGS; ANIMALS
- Publication
Journal of Interventional Cardiac Electrophysiology, 2020, Vol 58, Issue 3, p281
- ISSN
1383-875X
- Publication type
journal article
- DOI
10.1007/s10840-019-00595-y