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- Title
A Facile Solid-Phase Synthesis of (+)-( S)-Clopidogrel.
- Authors
Jung, Kiwon; Kim, Jae-Sun; Kim, Tae-Hyun; Kim, Jinwoong
- Abstract
Enantiomerically pure (+)-( S)-clopidogrel was prepared by solid-phase synthesis using the commercially available Wang resin. This method offers mild reaction conditions and provides the (+)-( S)-clopidogrel in overall 52% yield over six steps and with optical purity of 98.0% ee.
- Subjects
CLOPIDOGREL; ADRENERGIC beta blockers; ANTICOAGULANTS; CARDIOVASCULAR agents; PLATELET aggregation inhibitors; SOLID-phase synthesis; ORGANIC synthesis
- Publication
Helvetica Chimica Acta, 2013, Vol 96, Issue 2, p326
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201200185