We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Genetic Determination of Osteoporosis: Lessons Learned from a Large Genome-Wide Linkage Study.
- Authors
Dong-Hai Xiong; Jin-Tang Wang; Wei Wang; Yan-Fang Guo; Peng Xiao; Hui Shen; Hui Jiang; Yuan Chen; Hongyi Deng; Drees, Betty; Recker, Robert R.; Hong-Wen Deng
- Abstract
Osteoporosis is a common disease with strong genetic control. We performed an autosomal linkage scan in a large pedigree-based sample of 4,498 subjects for a composite osteoporosis phenotype that combines osteoporotic fracture (OF) and low bone mineral density (BMD). All of the subjects were U.S. Caucasians recruited in the Omaha area of Nebraska. Sex-specific linkage analyses and autosomal imprinting analyses were also conducted. For conventional linkage analyses in the total sample, we identified suggestive linkage on chromosomes 14q32 (LOD = 2.61), 7p14 (LOD = 2.42), and 11q25 (LOD = 2.09). In female subjects a significant linkage signal was detected on chromosome 14q22 (LOD = 3.53) and another two peaks were detected on chromosomes 7p14 (LOD = 3.07) and 9p21 (LOD = 2.29). Suggestive evidence of imprinted loci was found with paternally derived alleles on chromosomes 1q42 (LOD=2.12) and 9q34 (LOD=1.88). Some evidence of linkage to maternally derived alleles was found on chromosome 7q22 (LOD = 1.67). Our study provides new clues to osteoporosis genetic research and for the first time suggests that genomic imprinting effects may play a role in the etiology of osteoporosis.
- Subjects
UNITED States; GENETIC sex determination; OSTEOPOROSIS; GENETICS; BONE density; CHROMOSOMES
- Publication
Human Biology, 2007, Vol 79, Issue 6, p593
- ISSN
0018-7143
- Publication type
Article
- DOI
10.1353/hub.2008.0018