We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Tramadol concentrations in blood and in cerebrospinal fluid in a neonate.
- Authors
Allegaert, K.; de Hoon, J.; Verbesselt, R.; Devlieger, H.; Tibboel, D.
- Abstract
Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.
- Subjects
DRUG therapy; OPIOIDS; EFFECT of drugs on newborn infants; CENTRAL nervous system; BLOOD; CEREBROSPINAL fluid; PHARMACOKINETICS
- Publication
European Journal of Clinical Pharmacology, 2005, Vol 60, Issue 12, p911
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-004-0872-7