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- Title
THE EFFECT OF ANTILYMPHOCYTE SERUM (ALS) ON THE SECONDARY IMMUNE RESPONSE IN MICE.
- Authors
Marshall, V. R.; Knight, P. R.
- Abstract
The article informs that Antilymphocyte serum (ALS) has been shown to prolong the survival of skin allografts and skin xenografts in experimental animals. The search for better immunosuppressive agents to prolong the survival of human renal allograft's led to assess its value in a series of 20 patients who were treated with ALS, in addition to standard immunosuppressive therapy after receipt of kidneys from living related donors. Although this material apparently enabled reduced quantities of other immunosuppressive agents to be used, its administration products side effects such as gross lymphopenia and wasting in mice, serum sickness nephritis, and severe pain at the site of injection, fever and anaphylactic reactions, winch would render its prolonged usage undesirable.
- Subjects
IMMUNOSUPPRESSIVE agents; TRANSPLANTATION of organs, tissues, etc.; ANTILYMPHOCYTIC serum; DISEASES; THERAPEUTICS; DRUGS
- Publication
Australian Journal of Experimental Biology & Medical Science, 1969, Vol 47, Issue 2, p275
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1969.28