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- Title
IN VITRO AND IN SILICO EVALUATION OF THE ANTIVIRAL POTENTIAL OF EUCALYPTUS ESSENTIAL OILS.
- Authors
AK-SAKALLI, Ezgi; KARADAĞ, Ayşe Esra; TERALI, Kerem; ÇELİK, İsmail; KOŞAR, Müberra; DEMİRCİ, Fatih
- Abstract
The members of the genus Eucalyptus L. belonging to the Myrtaceae are well-known and have been utilized for millennia as aromatic and medicinal plants. Due to their antibacterial and antioxidant properties, eucalyptus essential oils are frequently used in flavorings, culinary preparations, as well as in medicinal and cosmetic applications. In the present study, in vitro enzyme inhibition assays were conducted for neuraminidase (NA), transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) to explore the antiviral potential of two different essential oils from Eucalyptus species. European-Pharmacopoeia-quality essential oils from E. globulus and E. citriodora were employed in the enzyme assays. The inhibitory activitiesof essential oils at 20 µg/mL against ACE2, TMPRSS2 and NA were measured using commercial kits. E. globulus essential oil inhibited ACE2, TMPRSS2 and NA by 94.3%,74.82% and 67.59%, respectively. E. citriodora essential oil inhibited ACE2, TMPRSS2 and NA by 83.4%, 60.55% and 43.64%, respectively. Although both essential oils fromthe Eucalyptus species demonstrated good enzyme inhibitory activity, our in vitro results indicated that E. globulus essential oil possesses greater antiviral activity potential than E. citriodora. Furthermore, protein-ligand docking and interaction profiling studies were utilized to gain structural and mechanistic insights into the in silico ACE2, TMPRSS2 and NA inhibitory potentials of the major constituents of Eucalyptus essential oil, 1,8-cineole and citronellal. The results corroborated the in vitro findings. In conclusion, based on the results obtained in this study, both eucalyptus essential oils exhibit antiviral potential, making them viable candidates against cold, flu, and coronavirus. Further in vivo studies are required to confirm their activity.
- Subjects
EUCALYPTUS; NEURAMINIDASE; ESSENTIAL oils; MOLECULAR docking; ANGIOTENSIN converting enzyme; AROMATIC plants; PROTEIN-ligand interactions
- Publication
Journal of Research in Pharmacy, 2023, Vol 27, p21
- ISSN
2630-6344
- Publication type
Article
- DOI
10.29228/jrp.578