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- Title
β 3 Relaxant Effect in Human Bladder Involves Cystathionine γ-Lyase-Derived Urothelial Hydrogen Sulfide.
- Authors
Mitidieri, Emma; Pecoraro, Annalisa; Esposito, Erika; Brancaleone, Vincenzo; Turnaturi, Carlotta; Napolitano, Luigi; Mirone, Vincenzo; Fusco, Ferdinando; Cirino, Giuseppe; Sorrentino, Raffaella; Russo, Giulia; Russo, Annapina; d'Emmanuele di Villa Bianca, Roberta
- Abstract
Keywords: hydrogen sulfide; urothelium; urothelium-derived relaxing factor; bladder; 3 adrenoceptor EN hydrogen sulfide urothelium urothelium-derived relaxing factor bladder 3 adrenoceptor N.PAG N.PAG 13 08/29/22 20220801 NES 220801 1. 3 Relaxant Effect in Human Bladder Involves Cystathionine -Lyase-Derived Urothelial Hydrogen Sulfide Since it is known that (i) SB 3 sb AR is expressed in the human detrusor and urothelium [[31]], and (ii) SB 3 sb AR stimulation relaxes the human corpus cavernosum through H SB 2 sb S release [[33]], here, we have investigated the contribution of the urothelium and the possible involvement of the H SB 2 sb S pathway in SB 3 sb -induced relaxation in the human bladder. Moreover, sodium hydrogen sulfide and L-cysteine (exogenous and endogenous sources of H SB 2 sb S, respectively) relax in a concentration-dependent manner human bladder strips precontracted with carbachol, indicating a relevant role for H SB 2 sb S in bladder homeostasis [[21]].
- Subjects
UROTHELIUM; HYDROGEN sulfide; BLADDER; CYSTATHIONINE; CALCIUM-dependent potassium channels; ADRENERGIC beta agonists; MUSCARINIC receptors; CYCLIC adenylic acid
- Publication
Antioxidants, 2022, Vol 11, Issue 8, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11081480