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- Title
An Enriched Environment Improves Sensorimotor Function Post-Ischemic Stroke.
- Authors
Janssen, Heidi; Bernhardt, Julie; Collier, Janice M.; Sena, Emily S.; McElduff, Patrick; Attia, John; Pollack, Michael; Howells, David W.; Nilsson, Michael; Calford, Mike B.; Spratt, Neil J.
- Abstract
Objective. An enriched environment (EE) refers to conditions that facilitate or enhance sensory, cognitive, motor, and social stimulation relative to standard (laboratory) conditions. Despite numerous published studies investigating this concept in animal stroke models, there is still debate around its efficacy. The authors performed a systematic review and meta-analysis to determine the efficacy of an EE on neurobehavioral scores, learning, infarct size, and mortality in animal models of ischemic stroke. Methods. Systematic review of controlled studies of the use of an EE in experimental stroke was conducted. Data extracted were analyzed using weighted mean difference meta-analysis. For pooled tests of neurobehavioral scores, a random effects standardized method was used. Results. Animals recovering in an EE poststroke had mean neurobehavioral scores 0.9 standard deviations (95% confidence interval [CI] = 0.5-1.3; P < .001) above the mean scores of animals recovering in standard conditions and showed a trend toward improvement in learning (25.1% improvement; 95% CI = 3.7-46.6; P = .02). There was no significant increase in death. Animals exposed to an EE had 8.0% larger infarcts than control animals (95% CI = 1.8-14.1; P = .015). Conclusions. The results indicate significant improvements in sensorimotor function with EE poststroke but suggest a small increase in infarct volume. Clarification of the underlying mechanisms requires further study but should not overshadow the observed functional improvements and their application to clinical trials during stroke rehabilitation.
- Subjects
ANALYSIS of variance; ANIMAL experimentation; BEHAVIOR; BIOLOGICAL models; CEREBROVASCULAR disease; CHI-squared test; CONFIDENCE intervals; CONVALESCENCE; EPIDEMIOLOGY; MEDICAL information storage &; retrieval systems; LABORATORY animals; LEARNING; LIFE skills; MEDLINE; META-analysis; MORTALITY; PSYCHOLOGY of movement; NEUROPLASTICITY; ONLINE information services; PROBABILITY theory; RATS; RESEARCH funding; SENSORY stimulation; DATA analysis; EFFECT sizes (Statistics); SOCIAL context; PATHOLOGY; PHYSICAL therapy
- Publication
Neurorehabilitation & Neural Repair, 2010, Vol 24, Issue 9, p802
- ISSN
1545-9683
- Publication type
Article
- DOI
10.1177/1545968310372092