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- Title
Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans.
- Authors
Schur, Ellen A.; Melhorn, Susan J.; Oh, Seok‐Kyun; Lacy, J. Matthew; Berkseth, Kathryn E.; Guyenet, Stephan J.; Sonnen, Joshua A.; Tyagi, Vidhi; Rosalynn, Mary; De Leon, B.; Webb, Mary F.; Gonsalves, Zenobia T.; Fligner, Corinne L.; Schwartz, Michael W.; Maravilla, Kenneth R.; Oh, Seok-Kyun
- Abstract
<bold>Objective: </bold>To use quantitative magnetic resonance imaging (MRI) to test whether mediobasal hypothalamic (MBH) gliosis is associated with obesity and insulin resistance in humans.<bold>Methods: </bold>Sixty-seven participants underwent a fasting blood draw and MRI. Cases with radiologic evidence of MBH gliosis (N = 22) were identified as the upper tertile of left MBH T2 relaxation time and were compared to controls (N = 23) from the lowest tertile. In a separate postmortem study, brain slices (N = 10) through the MBH were imaged by MRI and stained for glial fibrillary acidic protein (GFAP).<bold>Results: </bold>In all participants, longer T2 relaxation time in the left MBH was associated with higher BMI (P = 0.01). Compared with controls, cases had longer T2 relaxation times in the right MBH (P < 0.05), as well as higher BMI (P < 0.05), fasting insulin concentrations (P < 0.01), and HOMA-IR values (P < 0.01), adjusted for sex and age. Elevations in insulin and HOMA-IR were also independent of BMI. In the postmortem study, GFAP staining intensity was positively associated with MBH T2 relaxation time (P < 0.05), validating an MRI-based method for the detection of MBH gliosis in humans.<bold>Conclusions: </bold>These findings link hypothalamic gliosis to insulin resistance in humans and suggest that the link is independent of the level of adiposity.
- Subjects
HYPOTHALAMUS; GLIOSIS; OBESITY; INSULIN resistance; MAGNETIC resonance imaging; FASTING; BLOOD testing; GLIAL fibrillary acidic protein; ADIPOSE tissue physiology; DEGENERATION (Pathology); HUMAN body composition; INSULIN; RESEARCH funding; CASE-control method; DIAGNOSIS
- Publication
Obesity (19307381), 2015, Vol 23, Issue 11, p2142
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21248