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- Title
Neonatal Exposure to Leptin Augments Diet-induced Obesity in Leptin-deficient Ob/Ob Mice.
- Authors
Yura, Shigeo; Itoh, Hiroaki; Sagawa, Norimasa; Yamamoto, Hiroshi; Masuzaki, Hiroaki; Nakao, Kazuwa; Kawamura, Makoto; Mogami, Haruta; Ogawa, Yoshihiro; Fujii, Shingo
- Abstract
The article presents the results of a study on the role of leptin in diet-induced obesity of neonatal wild-type (wt) mice. Fetal weight gains of mice with maternal food restriction (UN) were lower than those from mothers fed with ad libitum. The body weight of wt-UN on a high-fat diet (HFD) was higher than wt mice in intrauterine undernutrition (NN). Leptin has increased the body weight of wt-UN than wt-NN.
- Subjects
LEPTIN; OBESITY in animals; LABORATORY mice; WEIGHT gain; ANIMAL nutrition; BODY weight
- Publication
Obesity (19307381), 2008, Vol 16, Issue 6, p1289
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1038/oby.2008.57