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- Title
Serum gastrin concentration in neonates with early-onset severe infections.
- Authors
Stojewska, Małgorzata; Oświęcimska, Joanna; Stachurska, Aneta; Szymańska, Anna; Staśkiewicz, Katarzyna; Godula-Stuglik, Urszula
- Abstract
Introduction. Effect of early-onset infections on serum gastrin concentration in neonates is not well known. Aim. The evaluation of serum gastrin concentration in neonates with regards to their sex, fetal maturity, type of delivery, occurrence of early-onset infections, birth asphyxia and gastrointestinal disorders. Material and methods. In 97 (54 full-term, 43 preterm) neonates, among them 54 infected and 43 healthy ones, twice serum gastrin concentration by radioimmunoassay was measured. Results. Infected full-term neonates in the first week of life had significantly higher gastrin concentration than infected preterm neonates and healthy full-term. In the third week of life, infected preterm neonates had higher mean gastrin value than healthy preterm and infected full-term neonates. Significant lower mean gastrin concentration was noted in infected full-term neonates with gastrointestinal disorders than in infected neonates without these signs. Prematurity and presence of early-onset infection in neonates were independent predictors of gastrin values in both measurements. Conclusions. 1. Differences in serum gastrin concentrations between full-term and preterm neonates may depend on early-onset severe infections connected with intensive therapy, on gastrointestinal tract maturity and functional disorders and type of nutrition. 2. Higher gastrin concentrations in infected full-term than in healthy neonates may proof stimulation gastrointestinal tract to gastrin secretion in response to infection. 3. Lower gastrin concentrations in infected preterm than in healthy and in infected full-term neonates may suggest their decrease ability to gastrin secretion in the first week of life. 4. Significantly increase gastrin concentration in the third week may be connected with better neonatal health, full enteral nutrition independently of infection in the past, birth asphyxia and neonatal sex.
- Subjects
DIAGNOSIS of neonatal diseases; GASTRIN; PREMATURE infants; EARLY diagnosis; GASTROINTESTINAL agents; RADIOIMMUNOASSAY
- Publication
Pediatric Endocrinology / Endokrynologia Pediatryczna, 2017, Vol 16, Issue 2, p101
- ISSN
1730-0282
- Publication type
Article
- DOI
10.18544/EP-01.16.02.1667