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- Title
Quantitative Contrast Sensitivity Function and the Effect of Aging in Healthy Adult Eyes: A Normative Database.
- Authors
Choi, Hanna; Vingopoulos, Filippos; Razavi, Peyman; Garcia, Mauricio D.; Garg, Itika; Rodriguez, Jocelyn; Finn, Matthew; Baldwin, Grace; Romano, Francesco; Xinyi Ding; Bannerman, Augustine; Tracy, Jack; Wescott, Hannah; Husain, Deeba; Kim, Leo A.; Vavvas, Demetrios G.; Miller, John B.
- Abstract
BACKGROUND AND OBJECTIVE: We sought to establish normative quantitative contrast sensitivity function (qCSF) values in healthy adult eyes and investigate the effect of age on qCSF. PATIENTS AND METHODS: Healthy eyes underwent qCSF testing (adaptive sensory technology) and Snellen’s visual acuity (VA). Descriptive statistics and mixed-effects multivariable linear regressions were evaluated. RESULTS: A total of 334 eyes (290 patients) with median age 61 years (range 21 to 88) had qCSF values as follows: area under the log contrast sensitivity function curve: 1.18; contrast acuity: 1.32; contrast sensitivity (CS) at 1 cycle per degree (cpd): 1.32; CS at 1.5 cpd: 1.37; CS at 3 cpd: 1.38; CS at 6 cpd: 1.20; CS at 12 cpd: 0.69; CS at 18 cpd: 0.22. Linear reductions in qCSF values per decade of age ranged from –0.02 to –0.07 vs 0.01 for visual acuity (VA). Age had a greater effect on the majority of qCSF values than VA (beta standardized regression coefficient ranged from –0.309 to –0.141 for qCSF values vs 0.177 for VA). CONCLUSIONS: We herein establish a normative database for qCSF and quantify the effect of age on qCSF values, adding evidence towards the validation of qCSF as a clinical endpoint.
- Publication
Ophthalmic Surgery, Lasers & Imaging Retina, 2024, Vol 55, Issue 4, p212
- ISSN
2325-8160
- Publication type
Article
- DOI
10.3928/23258160-20240124-01