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- Title
New parameters of the 8th edition AJCC/UICC T category in nasopharyngeal carcinoma: Cervical vertebrae invasion and parotid gland invasion.
- Authors
Guo, Rui; Wang, Shun‐Xin; Hu, Yong; Liang, Shao‐Bo; Tang, Ling‐Long; Liu, Li‐Zhi; Tian, Li; Luo, Xiao‐Tong; Ma, Jun; Mao, Yan‐Ping
- Abstract
Dear Editor, The anatomic extent or stage of cancer provides the critical benchmarks and standards for defining prognosis and for determining the best treatment approach, and it also presents stratification criteria for clinical trials and consistent nomenclature for exchanging experience.1,2 The AJCC/UICC TNM staging system is widely used in tumor staging worldwide due to its periodic revision supported by high-quality evidence.1,2 In response to the better delineation of tumor extent resulting from advances in imaging techniques, the latest released 8th edition staging system of nasopharyngeal carcinoma (NPC) empirically introduces cervical vertebrae invasion (CVI) into T3 and parotid gland invasion (PGI) into T4. The 5-year OS of patients in T2'-3' group with CVI and/or PGI ranged from 67% to 75%, which was worse than that of patients in T2'-3' group without CVI/PGI (86%), and comparable to that of patients in T4' (77%). The presence of CVI/PGI was associated with advanced disease and poor prognosis, which served as evidence for the introduction of CVI and PGI into the 8th edition T category.
- Subjects
CERVICAL vertebrae; NASOPHARYNX cancer; PAROTID glands; NASOPHARYNX; INSTITUTIONAL review boards; PTERYGOID muscles
- Publication
Clinical & Translational Medicine, 2020, Vol 10, Issue 7, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.202