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- Title
Predictors of psychosis: a 50-year follow-up of the Lundby population.
- Authors
Bogren, Mats; Mattisson, Cecilia; Tambs, Kristian; Horstmann, Vibeke; Munk-Jørgensen, Povl; Nettelbladt, Per
- Abstract
Behavioural and neuropsychological vulnerability have been associated with an increased risk of psychosis. We investigated whether certain clusters of premorbid behavioural and personality-related signs and symptoms were predictors of nonaffective and/or affective psychosis and schizophrenia, respectively, in a 50-year follow-up of an unselected general community population. Total population cohorts from the same catchment area in 1947 ( n = 2,503) and 1957 ( n = 3,215) that had been rated for behavioural items and enduring symptoms were followed up to 1997 regarding first-incidence of DSM-IV nonaffective and/or affective psychosis. Attrition was 1–6%. The influence of the background factors, aggregated in dichotomous variables (predictors), on time to occurrence of nonaffective and/or affective psychosis was assessed by means of Cox regression models. In multivariate models the predictors nervous-tense, blunt-deteriorated, paranoid-schizotypal and tired-distracted were significantly associated with subsequent nonaffective and/or affective psychosis. In simple models, down-semidepressed, sensitive-frail and easily hurt were significantly associated with development of psychosis. When schizophrenia was analysed separately nervous-tense remained significant in the multivariate model, although blunt-deteriorated, paranoid-schizotypal and tired-distracted did not; and abnormal-antisocial reached significance. To conclude, we found some evidence for anxiety-proneness, affective/cognitive blunting, poor concentration, personality cluster-A like traits and interpersonal sensitivity to be associated with general psychosis vulnerability.
- Subjects
DENMARK; PSYCHOSES; SCHIZOPHRENIA; MENTAL illness; AFFECTIVE disorders; LUNDBY Site (Denmark)
- Publication
European Archives of Psychiatry & Clinical Neuroscience, 2010, Vol 260, Issue 2, p113
- ISSN
0940-1334
- Publication type
Article
- DOI
10.1007/s00406-009-0022-4