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- Title
Reversal of hypercalcemic acute kidney injury by treatment with intravenous bisphosphonates.
- Authors
Auron, Ari; Tal, Leyat; Srivastava, Tarak; Alon, Uri S.
- Abstract
We present the details of three children with hypercalcemia-induced acute kidney injury (AKI). After traditional therapy with fluids, loop diuretics, steroids and calcitonin had failed to correct the hypercalcemia, they were given treatment with low doses of intravenous (i.v.) pamidronate, which resulted in normalization of serum calcium and kidney function. In one child Doppler renal ultrasound revealed dampened arterial blood flow, which resolved with normalization of serum calcium. On the basis of cumulative data and our experience, we suggest that i.v. application of bisphosphonates be moved from the second to the first line of treatment of hypercalcemic AKI.
- Subjects
ACUTE kidney failure in children; HYPERCALCEMIA; INTRAVENOUS therapy for children; DISODIUM pamidronate; DIPHOSPHONATES; RENAL artery; BLOOD flow; THERAPEUTICS
- Publication
Pediatric Nephrology, 2009, Vol 24, Issue 3, p613
- ISSN
0931-041X
- Publication type
Report
- DOI
10.1007/s00467-008-1011-y