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- Title
Tumor suppressor TNFAIP3 (A20) is frequently deleted in Sézary syndrome.
- Authors
Braun, F. C. M.; Grabarczyk, P.; Möbs, M.; Braun, F. K.; Eberle, J.; Beyer, M.; Sterry, W.; Busse, F.; Schröder, J.; Delin, M.; Przybylski, G. K.; Schmidt, C. A.; Möbs, M; Schröder, J
- Abstract
Despite recent therapeutic improvements, the prognosis for patients suffering from Sézary syndrome (SS), a disseminated form of cutaneous T-cell lymphomas, is still poor. We identified bi- and monoallelic deletions of the tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) in a high proportion of SS patients as well as biallelic A20 deletion in the SS-derived cell line SeAx. Furthermore, we demonstrate that inhibition of A20 activates the NF-κB pathway thereby increasing the proliferation of normal T lymphocytes. On the other hand, the reconstitution of A20 expression slowed down the cell cycle in SeAx cells. Recently A20 inactivation has been reported in various B-cell lymphomas. In this study, we show that A20 is also a putative tumor suppressor in the T-cell malignancy-SS.
- Subjects
TUMOR suppressor genes; SEZARY syndrome; CELL cycle; APOPTOSIS; T-cell lymphoma; COMPARATIVE studies; CYTOGENETICS; IMMUNOLOGY technique; RESEARCH methodology; MEDICAL cooperation; GENETIC mutation; ONCOGENES; POLYMERASE chain reaction; RESEARCH; RNA; SKIN tumors; T cells; WESTERN immunoblotting; DNA-binding proteins; EVALUATION research; NUCLEAR proteins; REVERSE transcriptase polymerase chain reaction; DNA methylation; SIGNAL peptides; CANCER cell culture; CHEMICAL inhibitors
- Publication
Leukemia (08876924), 2011, Vol 25, Issue 9, p1494
- ISSN
0887-6924
- Publication type
journal article
- DOI
10.1038/leu.2011.101