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- Title
Cutaneous angiosarcoma afflicting the lower aspect of the left leg in an elderly woman.
- Authors
Huber, Margit A.; Weber, Lutz; Kaskel, Peter; Warszawski, Antje; Schmidt, Roland; Peter, Ralf U.; Krähn, Gertraud
- Abstract
An 88-year-old woman who was generally in good health was referred to the Dermatology Department in August 1997. Three years prior to admission she had first noticed a bluish macule on her left Iower leg which had rapidly enlarged over the past 3 months. Other symptoms included intermittent bleeding and pain. On examination, there was an exophytic and partly exulcerated tumor of approximately 9 × 7 cm in diameter, Iocated above the left medial malleolus. The remainder of the Iower aspect of the left leg was without pathologic findings. The patient had not undergone surgery or radiotherapy prior to the described symptoms. Blood hematology, chemistry, immunologic and serologic parameters (including liver function tests) were within the normal range. The alkaline phosphatase decreased from 211 U/L initially to 179 U/L. Magnetic resonance imaging (MRI) of the left Iower leg revealed a 10 × 5 × 2 cm tumor mass invading the subcutaneous fat, leaving muscle tissue. Ultrasound of the regional lymph nodes, a chest X-ray, and a full-chest computed tomography (CT) scan were normal. A biopsy specimen showed a marked proliferation of cells of undifferentiated morphology in the corium and subcutaneous tissue. Several layers of atypical endothelial cells next to large cuboid cells with pleomorphic nuclei and frequent mitoses were noted, thus facilitating clear differentiation from Kaposi's sarcoma (Fig. 1). Immunohistochemical studies were positive for factor VIIl-related antigen, ulex europaeus I, CD31, and CD34. An angiosarcoma was diagnosed. Treatment included a complete surgical excision of the tumor with a wide safety margin of normal tissue. The skin defect was covered with mesh-graft. At this point, the patient refused consent to adjuvant radiation therapy postoperatively. In January 1998 and in March 1998 recurrences of the tumor were again treated with local excision and mesh-graft. Subsequent to multifocal recurrence in June 1998 (Fig. 2A), th...
- Subjects
ANGIOSARCOMA; CUTANEOUS manifestations of general diseases; LEG; TUMORS
- Publication
International Journal of Dermatology, 2000, Vol 39, Issue 6, p458
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1046/j.1365-4362.2000.00981-1.x