We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Circulating Insulin-Like Growth Factor-Binding Protein 3 Levels, Independent of Insulin-Like Growth Factor 1, Associate with Truncal Fat and Systolic Blood Pressure in South Asian and White European Preschool Children.
- Authors
Patel, Leena; Whatmore, andrew; Davies, Jill; Bansal, Narinder; Vyas, avni; Gemmell, Isla; Oldroyd, John; Cruickshank, J. Kennedy; Clayton, Peter
- Abstract
Aims: To study the effect of the insulin-like growth factor (IGF) system on growth, adiposity and systolic blood pressure (SBP) in early life in British-born South Asian (SA) and White European (WE) children. Methods: The effect of IGF-1 and insulin-like growth factor-binding protein 3 (IGFBP-3) over the first 4 years in 204 healthy SA and WE children was investigated by mixed linear regression modelling. This enabled inclusion of all follow-up observations and adjustment for repeated measures. Results: At birth, SA babies were shorter and lighter than WE babies. Over 4 years, SA ethnicity was associated with lower height, weight and body mass index (BMI) standard deviation score (SDS), higher subscapular/triceps skinfold thickness (Ss/Tr SFT) and lower SBP (all p < 0.01). IGF-1 was associated with greater height (p = 0.03), weight (p < 0.001) and BMI SDS (p < 0.001), and IGFBP-3 with greater weight SDS (p < 0.001), BMI SDS (p = 0.001), Ss/Tr SFT (p = 0.003) and SBP (p = 0.023). Conclusions: Over this first 4-year period of life, SA ethnicity was associated with being shorter, lighter, having more superficial truncal adiposity and lower SBP. IGFBP-3 (and not IGF-1) was independently associated with both superficial truncal adiposity and SBP, suggesting that IGFBP-3 is a potential metabolic and cardiovascular marker in healthy children in the early years of life. © 2013 S. Karger AG, Basel
- Subjects
INSULIN-like growth factor-binding proteins; SOMATOMEDIN C; CHILDHOOD obesity; REGRESSION analysis; SYSTOLIC blood pressure; PRESCHOOL children; SOUTH Asians; EUROPEANS; HEALTH
- Publication
Hormone Research in Paediatrics, 2014, Vol 81, Issue 2, p109
- ISSN
1663-2818
- Publication type
Article
- DOI
10.1159/000355824