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- Title
Weight loss during follow-up in patients with acute heart failure: From the KCHF registry.
- Authors
Seko, Yuta; Kato, Takao; Morimoto, Takeshi; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Shiba, Masayuki; Yamamoto, Erika; Yoshikawa, Yusuke; Kitai, Takeshi; Yamashita, Yugo; Iguchi, Moritake; Nagao, Kazuya; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige
- Abstract
Backgrounds: The prognostic implication of weight loss after discharge from acute heart failure (AHF) remains unclear. We sought to investigate the association of weight loss between discharge and 6-month visit with subsequent clinical outcomes in patients with AHF. Methods: We analyzed 686 patients with AHF in the prospective longitudinal follow-up study derived from the Kyoto Congestive Heart Failure registry, and divided them into 2 groups based on the weight loss at 6-month index visit. We defined the weight loss as ≥ 5% decrease in body weight from discharge to 6-month index visit. Results: There were 90 patients (13.1%) with a weight loss at 6-month visit. Patients in the weight loss group compared with those in the no weight loss group had higher body weight at discharge and lower body weight at 6-mont visit. Patients in the weight loss group had a lower systolic blood pressure, higher brain-type natriuretic peptide, lower serum albumin, lower hemoglobin, higher prevalence of heart failure with reduced ejection fraction at 6-month visit, and a lower prescription rate of inhibitors of renin-angiotensin system than those in the no weight loss group. The cumulative 6-month incidence of all-cause death was significantly higher in the weight loss group than in the no weight loss group (14.2% and 4.3%, log-rank P<0.001). The excess adjusted risk of the weight loss group relative to the no weight loss group remained significant for all-cause death (HR 2.39, 95%CI 1.01–5.65, P = 0.048). Conclusion: Body weight loss of ≥5% at 6-month visit after discharge was associated with subsequent all-cause death in patients with AHF.
- Subjects
NEPRILYSIN; BRAIN natriuretic factor; WEIGHT loss; HEART failure patients; SYSTOLIC blood pressure; CONGESTIVE heart failure; BODY weight
- Publication
PLoS ONE, 2023, Vol 17, Issue 6, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0287637